2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W096129
    Cl-PEG4-acid 158553-98-1 98.0%
    Cl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cl-PEG4-acid
  • HY-140256
    NH-bis(PEG2-C2-Boc) 1964503-36-3 ≥98.0%
    NH-bis(PEG2-C2-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis(PEG2-C2-Boc)
  • HY-140258
    NH-bis(PEG4-Boc) 2055041-41-1 98.0%
    NH-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis(PEG4-Boc)
  • HY-120237
    m-PEG7-Amine 170572-38-0 98.0%
    m-PEG7-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG7-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG7-Amine
  • HY-130599
    Hydroxy-PEG2-CH2-Boc 149299-82-1
    Hydroxy-PEG2-CH2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    Hydroxy-PEG2-CH2-Boc
  • HY-140037
    Mal-​PEG4-​propargyl 1262681-30-0 99.68%
    Mal-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Mal-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Mal-​PEG4-​propargyl
  • HY-140497
    Hydroxy-PEG2-CH2COOH 51951-04-3
    Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG2-CH2COOH
  • HY-140771
    Azido-PEG1-PFP ester 1807505-32-3
    Azido-PEG1-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-PFP ester
  • HY-130231
    m-PEG2-acid 149577-05-9
    m-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG2-acid
  • HY-140758
    Azido-PEG9-NHS ester 2801772-87-0 98.0%
    Azido-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG9-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG9-NHS ester
  • HY-135926
    Cbz-NH-PEG1-CH2CH2COOH 1205751-19-4 98.80%
    Cbz-NH-PEG1-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-NH-PEG1-CH2CH2COOH
  • HY-43055
    Cl-PEG2-acid 170304-76-4
    Cl-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cl-PEG2-acid
  • HY-138395
    DSPE-PEG6-Mal
    DSPE-PEG6-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG6-Mal
  • HY-130387
    Propargyl-PEG4-Tos 875770-32-4 99.25%
    Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG4-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-Tos
  • HY-140858
    Azido-PEG4-4-nitrophenyl carbonate 1422540-98-4 98.88%
    Azido-PEG4-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-4-nitrophenyl carbonate is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-4-nitrophenyl carbonate
  • HY-44141
    tert-Butyl 3-(2-iodoethoxy)propanoate 2296723-16-3
    tert-Butyl 3-(2-iodoethoxy)propanoate is a PROTAC linker, which refers to the PEG composition. tert-Butyl 3-(2-iodoethoxy)propanoate can be used in the synthesis of PROTAC FAK degrader 1 (HY-119932).
    tert-Butyl 3-(2-iodoethoxy)propanoate
  • HY-140520
    N-(acid-PEG3)-N-bis(PEG3-azide) 2182602-17-9 98.07%
    N-(acid-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(acid-PEG3)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(acid-PEG3)-N-bis(PEG3-azide)
  • HY-130399
    Mal-amido-PEG6-acid 1334177-79-5 99.33%
    Mal-amido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG6-acid
  • HY-141218
    m-PEG10-alcohol 27425-92-9
    m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG10-alcohol
  • HY-140278
    DBCO-PEG4-PFP ester
    DBCO-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG4-PFP ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-PFP ester
PROTAC Linkers Isoform Comparison

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